Faecal Calprotectin Testing at ELHT: Guidance for the use in Adults in Primary Care
The Faecal Calprotectin (FCP) test
Faecal calprotectin (FCP) is a biochemical test that allows the detection of intestinal inflammation through stool analysis. Inflammation increases activity of immune cells e.g. neutrophil granulocytes which release calprotectin. FCP is elevated in inflammatory bowel diseases (IBD) e.g. Crohn’s disease and ulcerative colitis and to a lesser extent in other conditions e.g. neoplasia and polyps.
The test has been recommended by National Institute of Clinical Excellence (NICE) as an option to support clinicians to distinguish between functional disorders (such as Irritable Bowel Syndrome – IBS) and Inflammatory Bowel Disease (IBD).
Why is the FCP test useful?
GP’s are happy managing most clear cases of IBS in primary care. Other patients are clearly more symptomatic with unacceptable frequency of defecation, blood in their stools or raised inflammatory markers. These patients clearly need a referral to gastroenterology, as they probably have a diagnosis of IBD.
There is a grey area in the middle though. Some patients have a lot of symptomology from IBS, but no clear features of IBD. Other patients are very anxious about their symptoms and want referral for reassurance. In these patients, a negative FCP test will reassure, avoiding unnecessary referral to secondary care and the need for further invasive investigation.
Although sigmoidoscopy or colonoscopy with biopsy is considered the ‘gold standard’ procedure for assessing intestinal inflammation it is invasive carrying a risk of complications and is uncomfortable for the patient. By prioritising the most appropriate patients for referral FCP testing may reduce the time required to make a diagnosis of IBD.
There is robust evidence to support the use of FCP as a marker for intestinal inflammation. FCP has been demonstrated to be sensitive and specific enough to be utilised for this purpose.
FCP testing has a high negative predictive value in the correct context and therefore allows clinicians to rule out intestinal inflammation with a degree of confidence.
However, if a clinician strongly suspects IBD on clinical grounds, FCP is not useful and a direct referral to secondary care is more appropriate.
Around 1g sample of faeces should be collected into a plain FECON container. Collect samples Monday- Thursday only to arrive in the laboratory on the day of collection. Do not freeze samples
Guidance for the use of FCP in Primary Care
|Clinical scenarios where FCP may be useful: |
Chronic diarrhoea with abdominal pain or discomfort that is relieved by defecation, or passage of mucus and bloating, where the clinician suspects IBS, but has a level of suspicion that there may be a diagnosis of IBD.
In patients who are very anxious about their symptoms, and want further investigation, and a negative test will reassure, and enable the GP to make the most appropriate decision regarding a referral.
Clinical scenarios where FCP is NOT appropriate:
Patients with a clear diagnosis of IBS where IBD is not suspected.
Suspected cancer – if cancer suspected use separate 2WR referral mechanism
Unexplained anaemia, weight loss or rectal bleeding – direct referral to secondary care is required
New onset GI symptoms in patients aged >50 yrs.
Avoid testing if there is known infectious diarrhoea, NSAID use, or current menstrual bleeding
FCP is an expensive test, and should be used within the limits of this guidance
| Arrange first line investigations |
Greater than 50ug/g
|Refer to gastroenterologist for further assessment (intestinal inflammation |
Less than 50ug/g
|Intestinal inflammation unlikely|
Secondary care investigation not usually necessary
Management in Primary Care appropriate including reassurance, information leaflets and symptomatic control with medication
Alternative causes of a raised FCP include:
- Gastro-intestinal infection/bleeding
- Colorectal neoplasia
- Non-steroidal anti-inflammatorydrug induced enteropathy
Please also see: https://www.nice.org.uk/Guidance/DG11
Please remember to use EMISQ2W1 when you are making a 2ww referral
Telephone: 0345 300 8090 (24 hrs)
Aftercare support: 0345 122 1441 (24 hrs)
Wednesday 08:30 – 16:30
Friday 08:30 – 16:30
Please note treatment times may occasionally differ from opening times. Call us anytime if you need clarification – 0345 300 8090 (24 hrs).
NHS Abortion treatment in Airedale, West Yorkshire is free if you have an NHS number.
Patients can call them direct to arrange treatment on 0345 300 8090 (24 hrs) providing you are registered with an NHS GP.
They provide assessment, ultrasound scan and medical termination. For surgical Termination of Pregnancy they refer on to Leeds Hospitals.
East Lancs Hospitals Trust also provide a good Pregnancy Counselling service – this is available via referral from your GP.
Information sheet with embedded documents relating to the LD Health Checks PLT Event which took place on the 20th May 2015
Scarlet Fever Update March 2015
This is intended for clinical staff only .
Heidi Willis (domiciliary phlebotomist) will now take referrals by way of the printed blood forms and labels instead of you needing to fill out the referral forms. Please pass the blood forms to me as normal and I will send them to her. Thanks.